Foldeomics Consortium

The Foldeomics Consortium consists of a group of experimental protein folding investigators, initially spanning 18 laboratories in eight countries. The goal of our efforts is to set uniform standards for the experimental community and to compile a dataset of the folding properties of a large number of reversibly folding proteins that will aid ongoing efforts to understand the folding process.

This work is described in more detail in Maxwell et al (2005) Protein folding: Defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins. Protein Science 14, pp 602-616.

We have updated the Protein Folding Database (PFD) along the guidelines set out by Maxwell et al. PFD is a searchable collection of all biophysical data relating to experimental protein folding studies, containing annotated structural, methodological, kinetic and thermodynamic data. PFD is described in more detail in Fulton et al (2005) Nucleic Acids Res. 33:D279.

NEW Ruczinski I, Sosnick TR, and Plaxco KW. Methods for the accurate estimation of confidence intervals on experimental Φ-values.

Foldeomics Consortium Members

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USA
David Wildes, Erik J. Miller, Susan Marqusee
Department of Molecular and Cell Biology, University of California, Berkeley. 		Kevin W. Plaxco, Miguel A. de los Rios
Department of Chemistry and Biochemistry, University of California, Santa Barbara. 		Jia-Cherng Horng, Daniel P. Raleigh
Department of Chemistry, State University of New York.
Pernilla Wittung-Stafshede
Biochemistry and Cell Biology Department and Chemistry Department Rice University.
 Tobin R. Sosnick
Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago. 		Ngoc-Diep Vu, Yawen Bai
Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health. Bethesda.
Ingo Ruczinski
Department of Biostatistics Bloomberg School of Public Health, Johns Hopkins University.
 Linlin Qiu, Stephen J. Hagen
Department of Physics, University of Florida.

AUSTRALIA
Ashley M Buckle, Kate F Fulton
The Department of Biochemistry and Molecular Biology
and Victorian Bioinformatics Consortium (VBC) Monash University, Melbourne.

CANADA
Karen L Maxwell, Diane Bona, Aled M. Edwards
Ontario Cancer Institute and Department of Medical Biophysics University of Toronto. 		Arash Zarrine-Afsar, Alan R. Davidson
Department of Biochemistry,University of Toronto.		 Alexis Vallée-Bélisle, Stephen W. Michnick
Département de Biochimie, Université de Montréal, Montréal.
Aled M. Edwards
Structural Genomics Consortium, University of Toronto. 		Aled M. Edwards, Alan R. Davidson
Department of Medical Genetics and Microbiology, University of Toronto.

UK

Andrew G. Brown, Ewan R. G. Main, Sophie E. Jackson
Laboratory of Biochemistry, Department of Chemistry, University of Cambridge.
Claire T. Friel, Sheena E. Radford
School of Biochemistry and Microbiology and Astbury Centre for Structural Molecular Biology, University of Leeds.

Italy
Francesco Bemporad, Fabrizio Chiti
Dipartimento di Scienze Biochimiche, Universita’ degli Studi di Firenze.

Denmark
Kaare Teilum, Flemming M. Poulsen, Birthe B. Kragelund
Institute of Molecular Biology, Department of Protein Chemistry, Copenhagen.

Sweden
Linda Hedberg, Mikael Oliveberg
Department of Biochemistry, Umea University.

Germany

Luis Serrano
European Molecular Biology Laboratory, Heidelberg.

Foldeomics Consortium
October 2006